In a 2nd food result research study of comparable style, 2 400 mg Skelaxin tablets (800 milligrams) were provided to healthy and balanced volunteers (N=59, 37 males, 22 girls), varying in age from 18-50 years (suggest age = 25.6 ± 8.7 years). As compared to fasted problems, the existence of a high fat meal at the time of medication management increased Cmax by 193.6 % and also enhanced AUC (AUC0-t, AUC ∞) by 146.4 % and also 142.2 %, respectively. Time-to-peak attention (Tmax) was additionally postponed (4.9 h versus 3.0 h) and also terminal half-life was decreased (4.2 h versus 8.0 h) under fed disorders as compared to fasted disorders. When one Skelaxin 800 mg tablet computer was provided in location of two Skelaxin 400 milligrams tablets, comparable meals impact results were noted in the above research. The boost in metaxalone direct exposure accompanying a decrease in half-life could be attributed to even more total absorption of metaxalone in the presence of a high fat dish (Figure 1).

Plasma protein binding and also downright bioavailability of metaxalone are not known, the obvious volume of distribution (V/F ~ 800 L) and lipophilicity (log P = 2.42) of metaxalone suggest that the drug is thoroughly distributed in the tissues. Metaxalone is metabolized by the liver as well as secreted in the urine as unidentified metabolites. Hepatic Cytochrome P450 enzymes play a role in the metabolic rate of metaxalone. Especially, CYP1A2, CYP2E1, cyp2d6, and cyp3a4 as well as, to a lower degree, CYP2C8, CYP2C9, and CYP2C19 appear to metabolize metaxalone.

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